2026/02/09

에릭 캔들 - 위키백과, Eric Kandel

에릭 캔들 - 위키백과, 우리 모두의 백과사전

에릭 캔들

위키백과, 우리 모두의 백과사전.
에릭 캔들
Eric Kandel
2013년 촬영
2013년 촬영
출생1929년 11월 7일(96세)
오스트리아 제1공화국 빈
국적미국
출신 학교뉴욕 대학교 의과대학(영어판)
하버드 대학교
수상딕슨상(1983년)
앨버트 래스커 기초 의학 연구상(1983년)
미국 국가 과학상(1988년)[1]
하비상(1993년)
울프 의학상(1999년)
노벨 생리학·의학상(2000년)
분야정신의학
정신분석학
신경과학
소속컬럼비아 대학교 의학대학원

에릭 리처드 캔들(영어: Eric Richard Kandel, 1929년 11월 7일 ~ )은 미국의 신경생리학자이다.[2] 뉴런의 기억 저장의 생리학적 기초에 대한 연구로 2000년 노벨 생리의학상을 받았다. 바다달팽이를 이용하여 '뇌 속 기억의 분자생물학적 메커니즘'을 밝혀낸 공로를 인정받은 결과였다.[3][2]

캔들의 저서 《기억을 찾아서》는 2006년 로스앤젤레스 타임즈의 과학기술부 도서상을 수상했으며 한국내에도 번역출판되어 소개되었다.[2] 그의 자서전인 이 책은 다큐멘터리 영화로도 제작되어 비평가들의 찬사를 받았다.[4]

생애

오스트리아 출신으로[2] 1939년 나치의 지배를 피해 가족과 함께 뉴욕 시 브루클린으로 이주하였다. 1944년 에라스무스 홀 고등학교(Erasmus Hall High School)을 졸업하고 같은해 하버드 대학교에 입학하여 1948년 역사학, 문학 학위를 수여받고 1952년 뉴욕대학교 메디컬 스쿨에서 생물학 박사 학위를 수여받았다. 1956년 뉴욕대학교 의과대학에서 의학박사 학위를 받았다.[5]

1957년 미국 국립 보건원의 신경 생리학 연구소 (Laboratory of Neurophysiology)에 합류했었고 1962년 정신과 레지던시를 수료한 뒤 해양연체동물에 대해 배우기위해 파리로갔다. 1965년 뉴욕대학교 의과대학 병리학 및 정신의학 부교수로 부임하여 1974년까지 근무했다.

1974년 컬럼비아대학교 의과대학 병리학 및 정신의학 교수로 자리를 옮겼고, 1984년 대학 부속의 하워드 휴즈 의학연구소 수석 연구원이 되었다. 1992년 이후 생화학 및 분자생물물리학 교수로 있다. 2000년에 신경계의 신호 전달에 대한 발견으로 아르비드 칼손, 폴 그린가드와 함께 노벨 생리학·의학상을 수상했다.

주요 연구

'뇌 속 기억의 분자생물학적 메커니즘'을 밝혀낸 것이 가장 큰 연구 업적이다. 그는 바다달팽이를 이용한 '수관-아가미 반사' 실험을 통해 뇌 속에서 기억 저장이 어떻게 형성되는가 하는 과정을 밝혀냈다.

그는 학습과 기억 작용이 일어날 때 시냅스에 어떤 변화가 발생하는지를 밝혔으며, 신경계에서 정보를 전달할 때 사용되는 뇌 시냅스의 효율성을 증가시킬 수 있는 방법도 발견했다. 또 인간의 단기 기억과 장기 기억이 신경세포의 분자 수준에서 서로 다르다는 점을 밝히기도 했다.[5]

미국의 의학자 폴 그린가드(Paul Greengard)와 신경생리학 분야에서의 공동 연구를 통해 신경세포의 신호전달체계를 밝혀내는 데 크게 기여했다. 이들은 도파민을 비롯한 수많은 신경전달물질이 구체적으로 어떤 과정을 거쳐 다른 신경세포에 신호를 전달하는지를 밝혔다.[5]

수상 경력

회원

서적

저서

  • Kandel, Eric R. (1976), 《Cellular Basis of Behaviour: An Introduction to Behavioural Neurobiology》, New York: W.H. Freeman & Company, ISBN 978-0-716-70522-2
  • Kandel, Eric R. (1978), 《A Cell - Biological Approach to Learning》, New York: Society for Neuroscience, ISBN 978-0-916-11007-9
  • Kandel, Eric R. (1979), 《Behavioural Bio of Aplysia: Origin & Evolution》, New York: W.H. Freeman & Company, ISBN 978-0-716-71070-7
  • Kandel, Eric R.; Schwartz, James H.; Jessell, Thomas M.; Siegelbaum, Steven A.; Hudspeth, A. J. (2012) [1981], 《Principles of Neural Science》 5판, New York: McGraw-Hill, ISBN 978-0-071-39011-8.
  • Kandel, Eric R. (1987), 《Molecular Neurobiology in Neurology and Psychiatry》, New York: Lippincott Williams & Wilkins, ISBN 978-0-881-67305-0
  • Kandel, Eric R.; Jessell, Thomas M. (1995), 《Essentials of Neural Science and Behaviour》, New York: McGraw-Hill/Appleton & Lange, ISBN 978-0-838-52245-5
  • Kandel, Eric R. (2005), 《Psychiatry, Psychoanalysis, and the New Biology of Mind》, New York: American Psychiatric Publishing, ISBN 978-1-585-62199-6
  • Kandel, Eric R. (2007), 《In Search of Memory: The Emergence of a New Science of Mind》, New York: W. W. Norton & Company, ISBN 978-0-393-32937-7.
  • Kandel, Eric R. (2012), 《The Age of Insight: The Quest to Understand the Unconscious in Art, Mind, and Brain, from Vienna 1900 to the Present》, New York: Random House, ISBN 978-1-4000-6871-5
  • Kandel, Eric R. (2016), 《Reductionism in Art and Brain Science: Bridging the Two Cultures》, New York: Columbia University Press, ISBN 978-0-231-17962-1

공저

각주

  1. Eric Kandel 보관됨 2014-08-10 - 웨이백 머신 - superstarsofscience.com
  2.  [네이버 지식백과] 에릭 캔들 [Eric Kandel] (해외저자사전, 2014. 5.)
  3. 신동선 <재능을 만드는 뇌신경 연결의 비밀> 더메이커 2017년 p104
  4. [브레인미디어] 노벨생리의학상 수상자 에릭 캔델........캔델의 저서 《기억을 찾아서:마음의 신과학 등장(In Search of Memory:The Emergence of a New Science of Mind)》은 자신의 체험과 과학적 지식을 총망라한, 하나의 통렬한 개인적 여행기다. 이 책은 최근 같은 제목의 다큐멘터리 영화로도 제작되어 비평가들의 찬사를 받았다.
  5.  [네이버 지식백과] 에릭 캔들 [Eric Richard Kandel] (두산백과 두피디아, 두산백과)
  6. “New Fellows 2013”. Royal Society. 2013년 7월 30일에 확인함.

외부 링크



==
저작
대표적인 저작으로서, 일본에서는 도쿠시마 문리 대학 대학원 의 약학연구과에서 래리 R. 스퀘어와의 공저서 『Memory: From Mind to Molecules』가 교재로서 이용된 것이 계기가 되어, 일반용으로 발매할 수 없는가 하는 이야기가 되어, 2013년에 코단샤보다 제2판의 일본어 번역인 「기억의 구조」가 상하권으로 나누어 블루백스 신서 로서 발행되었다.

『칸델 신경과학( Principles of Neural Science )』( 가나자와 이치로 미야 시타 보지 일본어판 감수　오카노 에이유키 감역, 메디컬 사이언스 인터내셔널, 2014년)는 신경 과학의 대표적인 텍스트로 알려져 있다.

기타 저작
「예술・무의식・뇌 정신의 심연에：세기말 빈에서 현대까지」」오이와 유리
「왜 뇌는 아트를 알 수 있을까 현대 미술사로부터 배우는 뇌과학 입문」타카하시 서 번역
「 뇌과학으로 풀리는 마음의 병 우울증・치매・의존증으로부터 예술과 창조성까지」오이와 유리
==

==

Eric Kandel

From Wikipedia, the free encyclopedia
Eric Kandel
Kandel in 2013
Born
Erich Richard Kandel

November 7, 1929 (age 96)
Vienna, Austria
EducationHarvard University (BA)
New York University (MD)
Known forPhysiology of learning and memory
Spouse
 
​
(m. 1956)​
Children2
AwardsKarl Spencer Lashley Award (1981)
Dickson Prize (1983)
Lasker Award (1983)
National Medal of GSS (1988)[1]
Harvey Prize (1993)
Wolf Prize in Medicine (1999)
Nobel Prize in Physiology or Medicine (2000)
Scientific career
FieldsPsychiatry, Psychoanalysis and Neuroscience
InstitutionsColumbia University College of Physicians and Surgeons
Notable studentsJames H Schwartz
Tom Carew
Kelsey C. Martin
Priya Rajasethupathy
Scott A. Small
Christopher Pittenger

Eric Richard Kandel (German: [ˈkandəl]; born Erich Richard Kandel,[2] November 7, 1929[3]) is an Austrian-born American[3] medical doctor who specialized in psychiatry. He was also a neuroscientist and a professor of biochemistry and biophysics at the College of Physicians and Surgeons at Columbia University. He was a recipient of the 2000 Nobel Prize in Physiology or Medicine for his research on the physiological basis of memory storage in neurons. He shared the prize with Arvid Carlsson and Paul Greengard.

Kandel was from 1984 to 2022 a Senior Investigator in the Howard Hughes Medical Institute.[4] He was in 1975 the founding director of the Center for Neurobiology and Behavior,[5] which is now the Department of Neuroscience at Columbia University.[6] He currently serves on the Scientific Council of the Brain & Behavior Research Foundation. Kandel's popularized account chronicling his life and research, In Search of Memory: The Emergence of a New Science of Mind,[7] was awarded the 2006 Los Angeles Times Book Prize for Science and Technology.

Early years

Eric's mother, Charlotte Zimels, was born in 1897 in Kolomyia, Pokuttya (modern Ukraine). She came from an Ashkenazi Jewish family. At that time Kolomyya was part of Austria-Hungary. His father, Hermann Kandel, was born in 1898 in Olesko, Galicia (then part of Austria-Hungary). At the beginning of World War I, his parents moved to Vienna, Austria, where they met and married in 1923.[citation needed]

Eric Kandel was born on November 7, 1929, in Vienna. Shortly after, Eric's father established a toy store. Although thoroughly assimilated and acculturated, the family sensed the Nazi danger and, unlike others, left Austria after the country had been annexed by Germany in March 1938 at great expense. As a result of Aryanization (Arisierung), attacks on Jews had escalated and Jewish property was being confiscated. When Eric was 9, he and his brother Ludwig, 14, boarded the Gerolstein at Antwerp, Belgium, and joined their uncle in Brooklyn on May 11, 1939, to be followed later by his parents.[8]

After arriving in the United States and settling in Brooklyn, Kandel was tutored by his grandfather in Judaic studies and was accepted at the Yeshiva of Flatbush, from which he graduated in 1944. He attended Brooklyn's Erasmus Hall High School in the New York City school system.[9]

Kandel's undergraduate major at Harvard was History and Literature. He wrote an undergraduate honors thesis on "The Attitude Toward National Socialism of Three German Writers: Carl Zuckmayer, Hans Carossa, and Ernst Jünger". While at Harvard, a place where psychology was dominated by the work of B. F. Skinner, Kandel became interested in learning and memory. However, while Skinner championed a strict separation of psychology, as its own level of discourse, from biological considerations such as neurology, Kandel's work is essentially centered on an explanation of the relationships between psychology and neurology.

The world of neuroscience was opened up to Kandel as a consequence of his favorite literature teacher at the time, Karl Viëtor's, sudden passing in 1951 and leaving Kandel's next term schedule at Harvard, besides feeling "deep personal loss" over Viëtor's death, unexpectedly empty.[10] Around that time Kandel had met Anna Kris, whose parents Ernst Kris and Marianne Rie were psychoanalysts from Sigmund Freud's Vienna-based circle. Freud was a pioneer in revealing the importance of unconscious neural processes, and his lines of thought are at the root of Kandel's interest in the biology of motivation and unconscious and conscious memory.[11] Kandel changed his course to pursue and began his M.D. program at New York University in 1952.

Medical school and early research

In 1952 he started at the New York University Medical School. By graduation he was firmly interested in the biological basis of the mind. During this time he met his future wife, Denise Bystryn. Kandel was first exposed to research in Harry Grundfest's laboratory, for six months in 1955-56, at Columbia University.[12] Grundfest was known for using the oscilloscope to demonstrate that conduction velocity during an action potential depends on axon diameter. The researchers Kandel interacted with were contemplating the technical challenges of intracellular recordings of the electrical activity of the relatively small neurons of the vertebrate brain.

After starting his neurobiological work in the difficult thicket of the electrophysiology of the cerebral cortex, Kandel was impressed by the progress that had been made by Stephen Kuffler using a much more experimentally accessible system: neurons isolated from marine invertebrates. After becoming aware of Kuffler's work in 1955, Kandel graduated from medical school and learned from Stanley Crain how to make microelectrodes that could be used for intracellular recordings of crayfish giant axons.

Karl Lashley, a well-known American neuropsychologist, had tried but failed to identify an anatomical locus for memory storage in the cortex of the brain. When Kandel joined the Laboratory of Neurophysiology at the US National Institutes of Health in 1957, William Beecher Scoville and Brenda Milner had recently described the patient HM, who had lost the ability to form new memories after removal of his hippocampus. Kandel took on the task of performing electrophysiological recordings from hippocampal pyramidal neurons. Working with Alden Spencer, he found electrophysiological evidence for action potentials in the dendritic trees of hippocampal neurons.[13] The team also noticed the spontaneous pacemaker-like activity of these neurons, as well as a robust recurrent inhibition in the hippocampus. They provided the first intracellular records of the electrical activity that underlies the epileptic spike (the intracellular paroxysmal depolarizing shift) and the epileptic runs of spikes (the intracellular sustained depolarization). But, with respect to memory, there was nothing in the general electrophysiological properties of hippocampal neurons that suggested why the hippocampus was special for explicit memory storage.

Kandel began to realize that memory storage must rely on modifications in the synaptic connections between neurons and that the complex connectivity of the hippocampus did not provide the best system for study of the detailed function of synapses. Kandel was aware that comparative studies of behavior, such as those by Konrad Lorenz, Niko Tinbergen, and Karl von Frisch had revealed that simple forms of learning were found even in very simple animals. Kandel felt it would be productive to select a simple animal model that would facilitate electrophysiological analysis of the synaptic changes involved in learning and memory storage. He believed that, ultimately, the results would be found to be applicable to humans. This decision was not without risk: many senior biologists and psychologists believed that nothing useful could be learned about human memory by studying invertebrate physiology.[14]

In 1962, after completing his residency in psychiatry, Kandel went to Paris to learn about the marine mollusk Aplysia californica from Ladislav Tauc. Kandel had realized that simple forms of learning such as habituation, sensitization, classical conditioning, and operant conditioning could readily be studied with ganglia isolated from Aplysia. "While recording the behavior of a single cell in a ganglion, one nerve axon pathway to the ganglion could be stimulated weakly electrically as a conditioned [tactile] stimulus, while another pathway was stimulated as an unconditioned [pain] stimulus, following the exact protocol used for classical conditioning with natural stimuli in intact animals."[citation needed] Electrophysiological changes resulting from the combined stimuli could then be traced to specific synapses. In 1965 Kandel published his initial results, including a form of presynaptic potentiation that seemed to correspond to a simple form of learning.

Faculty member at New York University Medical School

Kandel in 1978

Kandel took a position in the Departments of Physiology and Psychiatry at the New York University Medical School, eventually forming the Division of Neurobiology and Behavior. Working with Irving Kupferman and Harold Pinsker, he developed protocols for demonstrating simple forms of learning by intact Aplysia. In particular, the researchers showed that the now famous gill-withdrawal reflex, by which the slug protects its tender gill tissue from danger, was sensitive to both habituation and sensitization. By 1971 Tom Carew had joined the research group and helped extend the work from studies restricted to short-term memory to experiments that included physiological processes required for long-term memory.

By 1981, laboratory members including Terry Walters, Tom Abrams, and Robert Hawkins had been able to extend the Aplysia system into the study of classical conditioning, a finding that helped close the apparent gap between the simple forms of learning often associated with invertebrates and more complex types of learning more often recognized in vertebrates.[15] Along with the fundamental behavioral studies, other work in the lab traced the neuronal circuits of sensory neurons, interneurons, and motor neurons involved in the learned behaviors. This allowed analysis of the specific synaptic connections that are modified by learning in the intact animals. The results from Kandel's laboratory provided solid evidence for the mechanistic basis of learning as "a change in the functional effectiveness of previously existing excitatory connections."[citation needed] Kandel's winning of the 2000 Nobel Prize in Physiology or Medicine was a result of his work with Aplysia on the biological mechanisms of memory storage.[15]

Molecular changes during learning

Starting in 1966 James Schwartz collaborated with Kandel on a biochemical analysis of changes in neurons associated with learning and memory storage. By this time it was known that long-term memory, unlike short-term memory, involved the synthesis of new proteins. By 1972 they had evidence that the second messenger molecule cyclic AMP (cAMP) was produced in Aplysia ganglia under conditions that cause short-term memory formation (sensitization). In 1974 Kandel moved his lab to Columbia University and became founding director of the Center for Neurobiology and Behavior. It was soon found that the neurotransmitter serotonin, acting to produce the second messenger cAMP, is involved in the molecular basis of sensitization of the gill-withdrawal reflex. By 1980, collaboration with Paul Greengard resulted in demonstration that cAMP-dependent protein kinase, also known as protein kinase A (PKA), acted in this biochemical pathway in response to elevated levels of cAMP. Steven Siegelbaum identified a potassium channel that could be regulated by PKA, coupling serotonin's effects to altered synaptic electrophysiology.

In 1983 Kandel helped form the Howard Hughes Medical Research Institute at Columbia devoted to molecular neural science. The Kandel lab then sought to identify proteins that had to be synthesized to convert short-term memories into long-lasting memories. One of the nuclear targets for PKA is the transcriptional control protein CREB (cAMP response element binding protein).[16] In collaboration with David Glanzman and Craig Bailey, Kandel identified CREB as being a protein involved in long-term memory storage. One result of CREB activation is an increase in the number of synaptic connections. Thus, short-term memory had been linked to functional changes in existing synapses, while long-term memory was associated with a change in the number of synaptic connections.

Experimental support for Hebbian learning

Some of the synaptic changes observed by Kandel's laboratory provide examples of Hebbian theory. One article describes the role of Hebbian learning in the Aplysia siphon-withdrawal reflex.[17]

The Kandel lab has also performed important experiments using transgenic mice as a system for investigating the molecular basis of memory storage in the vertebrate hippocampus.[18][19][20] Kandel's original idea that learning mechanisms would be conserved between all animals has been confirmed. Neurotransmitters, second messenger systems, protein kinases, ion channels, and transcription factors like CREB have been confirmed to function in both vertebrate and invertebrate learning and memory storage.[21][22]

Continuing work at Columbia University

Since 1974, Kandel actively contributes to science as a member of the Division of Neurobiology and Behavior at the Department of Psychiatry at Columbia University. In 2008, he and Daniela Pollak discovered that conditioning mice to associate a specific noise with protection from harm, a behavior called "learned safety", produces a behavioral antidepressant effect comparable to that of medications. This finding, reported in Neuron,[23] may inform further studies of the cellular interactions between antidepressants and behavioral treatments.

Kandel is also well known for the textbooks he has helped write, such as Principles of Neural Science.[24] First published in 1981 and now in its sixth edition, the book is often used as a teaching and reference text in medical schools and undergraduate and graduate programs. Kandel has been a member of the National Academy of Sciences since 1974.[25]

Eric Kandel autographed baseball SfN 2009
Eric Kandel autographed baseball SfN 2009

He has also been at Columbia University since 1974 and lives in New York City.

Notable former members of his lab

  • James H. Schwartz 1964–1972: Coauthor of the influential textbook Principles of Neural Science.[26]
  • John H. (Jack) Byrne 1970–1975: Professor and Director of the Neuroscience Research Center at UT Health Science Center (Mcgovern Medical School); founder and editor of the research journal Learning and Memory.[27]
  • Tom Carew 1970–1983: Professor and Dean of the Faculty of Arts and Sciences at New York University, Center for Neural Science. Past President of the Society for Neuroscience.[28]
  • Edgar T. Walters 1974–1980: Professor at the Medical School of the University of Texas Health Science Center at Houston.[29]
  • Kelsey C. Martin 1992–1999: Dean of the David Geffen School of Medicine at UCLA and Professor in the Departments of Biological Chemistry, Psychiatry, and Biobehavioral Sciences.[30]

Current views about Vienna

When Kandel won the Nobel Prize in 2000, initially the media reported of an "Austrian" Nobel Prize winner, phrasing that Kandel found "typically Viennese: very opportunistic, very disingenuous, somewhat hypocritical". He also said it was "certainly not an Austrian Nobel, it was a Jewish-American Nobel". After that, he got a call from then Austrian president Thomas Klestil asking him, "How can we make things right?" 

Kandel said that first, Doktor-Karl-Lueger-Ring should be renamed; Karl Lueger was an anti-Semitic mayor of Vienna, cited by Hitler in Mein Kampf. The street was ultimately renamed in 2012 into Universitätsring.[31] 

Second, he wanted the Jewish intellectual community to be brought back to Vienna, with scholarships for Jewish students and researchers.[32] He also proposed a symposium on the response of Austria to Nazism,[33] which at that time had been wanting greatly.[34] Kandel has since accepted an honorary citizenship of Vienna and participates in the academic and cultural life of his native city,[35] similar to Carl Djerassi. 

Kandel's 2012 book, The Age of Insight—as expressed in its subtitle, The Quest to Understand the Unconscious in Art, Mind, and Brain, from Vienna 1900 to the Present[36]—represents a wide-ranging historical attempt to place Vienna at the root of cultural modernism by focussing on the personal interconnections between doctors such as Carl von Rokitansky, Emil Zuckerkandl, Sigmund Freud, with artists such as Gustav Klimt, Egon Schiele and Oskar Kokoschka and the writer Arthur Schnitzler, all of whom engaged with the "unconscious" in one way or another and influenced, Kandel claims, one another in the tight-knit salon of Berta Zuckerkandl and related occasions.[37]

Awards

Filmography

Selected publications

Books

Articles

See also

References

  1.  "Eric R. Kandel - A Superstar of Science". superstarsofscience.com. Archived from the original on 10 August 2014. Retrieved 4 May 2018.
  2.  "Eric R. Kandel". www.geschichtewiki.wien.gv.at (in German). Retrieved 2024-08-31.
  3.  "Eric R. Kandel Curriculum Vitae". nobelprize.org. Retrieved 10 October 2018.
  4.  "Eric R. Kandel, MD | Investigator Emeriti | 1984-2022".
  5.  "Eric Kandel". 6 March 2017.
  6.  "Neuroscience". 24 June 2022.
  7.  Kandel, Eric R. (2006). In Search of Memory: The Emergence of a New Science of Mind. W. W. Norton & Company. ISBN 978-0-393-32937-7.
  8.  Kandel, Eric R. 2006. In Search of Memory. New York: Norton, p. 31—32.
  9.  Eric R. Kandel: The Nobel Prize in Physiology or Medicine 2000, Nobel Foundation. Retrieved December 27, 2019. "My grandfather and I liked each other a great deal, and he readily convinced me that he should tutor me in Hebrew during the summer of 1939 so that I might be eligible for a scholarship at the Yeshiva of Flatbush, an excellent Hebrew parochial school that offered both secular and religious studies at a very high level. With his tutelage I entered the Yeshiva in the fall of 1939. By the time I graduated in 1944 I spoke Hebrew almost as well as English, had read through the five books of Moses; the books of Kings, the Prophets and the Judges in Hebrew; and also learned a smattering of the Talmud ... In 1944, when I graduated from the Yeshiva of Flatbush elementary school, it did not have a high school yet. So I went instead to Erasmus Hall High School, a local public high school in Brooklyn that was then academically very strong."
  10.  Kandel, Eric R. 2006. In Search of Memory. New York: Notron, pp. 38—39.
  11.  "Center for Eric Kandel Studies: (1) Sigmund Freud". Center for Eric Kandel Studies. Retrieved 2024-08-31.
  12.  Kandel, Eric R. 2006. In Search of Memory. New York: Norton, p. 56
  13.  Larkin, M. (2000). "The Lancet". Lancet. 356 (9237): 1250. doi:10.1016/S0140-6736(05)73856-3. PMID 11072956.
  14.  "Kaiser Foundation". 10 March 2020. Kandel's discoveries showed that a simple animal model could provide unparalleled insight into the mysteries of the human condition.
  15.  Edythe McNamee and Jacque Wilson (14 May 2013). "A Nobel Prize with help from sea slugs". CNN. Retrieved 2020-11-16.
  16.  Kandel, Eric R. (May 14, 2012). "The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB". Molecular Brain. 5: 14. doi:10.1186/1756-6606-5-14. ISSN 1756-6606. PMC 3514210. PMID 22583753.
  17.  Antonov, Igor; Antonova, Irina; Kandel, Eric R.; Hawkins, Robert D. (2003). "Activity-Dependent Presynaptic Facilitation and Hebbian LTP Are Both Required and Interact during Classical Conditioning in Aplysia". Neuron. 37 (1): 135–147. doi:10.1016/S0896-6273(02)01129-7. ISSN 0896-6273. PMID 12526779. S2CID 7839933.
  18.  Huang, Yan-You; Zakharenko, Stanislav S.; Schoch, Susanne; Kaeser, Pascal S.; Janz, Roger; Südhof, Thomas C.; Siegelbaum, Steven A.; Kandel, Eric R. (2005). "Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation". PNAS. 102 (26): 9365–9370. Bibcode:2005PNAS..102.9365H. doi:10.1073/pnas.0503777102. PMC 1166627. PMID 15967982.
  19.  Kojima, Nobuhiko; Wang, Jian; Mansuy, Isabelle M.; Grant, Seth G. N.; Mayford, Mark; Kandel, Eric R. (1997). "Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene". PNAS. 94 (9): 4761–4765. Bibcode:1997PNAS...94.4761K. doi:10.1073/pnas.94.9.4761. PMC 20798. PMID 9114065..
  20.  Brandon, E. P.; Zhuo, M.; Huang, Y. Y.; Qi, M.; Gerhold, K. A.; Burton, E. R.; Kandel, G. S.; McKnight, R. L.; Idzerda (1995). "Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase". PNAS. 92 (19): 8851–8855. Bibcode:1995PNAS...92.8851B. doi:10.1073/pnas.92.19.8851. PMC 41065. PMID 7568030.
  21.  Bailey, Craig H.; Bartsch, Dusan; Kandel, Eric R. (1996), "Toward a molecular definition of long-term memory storage", PNAS, 93 (24): 13445–13452, Bibcode:1996PNAS...9313445B, doi:10.1073/pnas.93.24.13445, PMC 33629, PMID 8942955
  22.  Kandel, Eric R. (2005), "The Molecular Biology of Memory Storage: A Dialog Between Genes and Synapses", Bioscience Reports, 24 (4–5): 475–522, doi:10.1007/s10540-005-2742-7, PMID 16134023, S2CID 17773633
  23.  Pollak DD, Monje FJ, Zuckerman L, Denny CA, Drew MR, Kandel ER (October 2008). "An animal model of a behavioral intervention for depression". Neuron. 60 (1): 149–61. doi:10.1016/j.neuron.2008.07.041. PMC 3417703. PMID 18940595.
  24.  Kandel, Eric R.; Schwartz, James H.; Jessell, Thomas M.; Siegelbaum, Steven A.; Hudspeth, A. J. (2012). Principles of Neural Science (5th ed.). McGraw-Hill. ISBN 978-0-07-139011-8.
  25.  "Eric R. Kandel". www.nasonline.org. Retrieved 2022-05-23.
  26.  Pearce, Jeremy (March 24, 2006). "Dr. James H. Schwartz, 73, Who Studied the Basis of Memory, Dies". The New York Times. Retrieved December 27, 2019.
  27.  "CV John H. Byrne" (PDF). Retrieved December 27, 2019.
  28.  "NYU/CNS : Faculty : Core Faculty: Thomas J. Carew". www.cns.nyu.edu. Archived from the original on October 2, 2017. Retrieved May 4, 2018.
  29.  "Edgar T. Walters, Ph.D." Archived from the original on June 16, 2013. Retrieved August 29, 2013.
  30.  "Kelsey C. Martin - Department of Biological Chemistry, UCLA". www.biolchem.ucla.edu. Retrieved December 27, 2019.
  31.  "Dr. Karl-Lueger-Ring to be renamed". Austrian Times. April 20, 2012. Archived from the original on March 7, 2014. Retrieved March 5, 2014.
  32.  "Newsmakers". Science. 320 (5881): 1269. June 6, 2008. doi:10.1126/science.320.5881.1269a. S2CID 220094511.
  33.  Nobel Prize Winner Kandel Speaks of Brain, Snails, Memory Pill Archived October 1, 2015, at the Wayback Machine, Bloomberg April 7, 2006.
  34.  Pick, Hella (2000). Guilty Victim.
  35.  "Late homage: Nobel Prize winner Eric Kandel becomes honorary citizen of Vienna". Jewish News. December 24, 2008. Archived from the original on December 26, 2019. Retrieved December 27, 2019.
  36.  Kandel, Eric R. (2012). The Age of Insight: The Quest to Understand the Unconscious in Art, Mind, and Brain, from Vienna 1900 to the Present. New York: Random House. ISBN 978-1-4000-6871-5.
  37.  Janik, Allan (2013). "Review of: The Age of Insight: The Quest to Understand the Unconscious in Art, Mind, and Brain from 1900 to the Present. By Eric B. Kandel. New York: Random House. 2012". Central European History. 46 (4): 913–916. doi:10.1017/s0008938914000156.
  38.  "Fellows of the American Academy of Arts and Sciences" (PDF). American Academy of Arts and Sciences. Retrieved December 27, 2019.
  39.  "APS Member History". search.amphilsoc.org. Retrieved 2022-05-23.
  40.  "NAS Award for Scientific Reviewing". National Academy of Sciences. Archived from the original on March 18, 2011. Retrieved February 27, 2011.
  41.  "The Nobel Prize in Physiology or Medicine 2000". Nobel Prize. Retrieved December 27, 2019.
  42.  "Reply to a parliamentary question" (PDF) (in German). p. 1709. Retrieved December 27, 2019.
  43.  "Benjamin Franklin Medal for Distinguished Achievement in the Sciences Recipients". American Philosophical Society. Retrieved December 27, 2019.
  44.  "Viktor Frankl Award". Retrieved December 27, 2019.
  45.  "New Fellows 2013". Royal Society. Retrieved December 27, 2019.
  46.  "Prize Committee in Neuroscience 2007–2008". Archived from the original on 24 June 2012. Retrieved March 5, 2014.
  47.  "Prize Committee in Neuroscience 2009–2010". Archived from the original on June 17, 2012. Retrieved March 5, 2014.
  48.  "Professor Eric Richard Kandel HonFRSE - The Royal Society of Edinburgh". The Royal Society of Edinburgh. Retrieved December 27, 2019.
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In Search of Memory: The Emergence of a New Science of Mind: Kandel, Eric R.: Amazon.com.au: Kindle Store

In Search of Memory: The Emergence of a New Science of Mind eBook : Kandel, Eric R.: Amazon.com.au: Kindle Store



In Search of Memory: The Emergence of a New Science of Mind Illustrated Edition, Kindle Edition
by Eric R. Kandel (Author)  Format: Kindle Edition
4.6 4.6 out of 5 stars   (449)
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“A stunning book.”—Oliver Sacks


Memory binds our mental life together. We are who we are in large part because of what we learn and remember. But how does the brain create memories? Nobel Prize winner Eric R. Kandel intertwines the intellectual history of the powerful new science of the mind—a combination of cognitive psychology, neuroscience, and molecular biology—with his own personal quest to understand memory. A deft mixture of memoir and history, modern biology and behavior, In Search of Memory brings readers from Kandel's childhood in Nazi-occupied Vienna to the forefront of one of the great scientific endeavors of the twentieth century: the search for the biological basis of memory.
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From Australia

Paul Gordon-Smith
5.0 out of 5 stars BRAIN, MIND and BIOLOGY
Reviewed in Australia on 17 July 2025
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This is the book you need to read to easily understand the underpinnings of psychiatry and know how important biology in its simplest form is to explain mind and the foundation of our genes and DNA.
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Joaquin Cabrera
5.0 out of 5 stars The best
Reviewed in Australia on 15 September 2023
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One of my favorite titles in my personal library. A book that will walk you through Kandel's childhood in Nazi Germany, psychology, neuroscience and molecular biology. I love this book
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Zipi Neustadt
5.0 out of 5 stars Highly recommended.
Reviewed in Australia on 26 April 2017
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Very interesting and a layman's path to understand the functioning of our brain. Highly recommended.
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Raghubir Singh Pirta
5.0 out of 5 stars Memories of fear and hatred!
Reviewed in India on 27 January 2020
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In Search of Memory is a wonderful journey with Eric Kandel. One learns about the trauma of nine years old child, who later explores how these traumatic memories are storedin the brain. And earns the Nobel Prize. The other issue before Kandel was to answer how does a most educated society gets infected by processes of Aryanization. For which he has only partial answer.
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Yoana
4.0 out of 5 stars The sending of books should be more careful
Reviewed in Mexico on 31 July 2019
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Dr. Kandel's work is fascinating, the shipping method was not the best, it arrived in an envelope that was broken in a corner to see the contents and therefore the edges of the book were slightly damaged
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Lars Komorowski
5.0 out of 5 stars Engrossing
Reviewed in Germany on 30 March 2014
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Nobel laureate Eric Kandel attractively links his personal biography with the uncovering of the biological foundations of the human mind, in which he played a significant part. You get a feeling, albeit not a deep understanding, of the network of cellular and biochemical functions that make up memory. This is due, on the one hand, to the fact that the book is necessarily written in popular science to reach the target group, and on the other hand, because, despite the impressive progress of the last 70 years, many connections are still hidden. But the book is quite suitable to give the impression that the brain is capable of understanding and decipher its own complexity.

In addition to a variety of interesting scientific anectdotes, facts and procedures, the working method of the American science system is also being stimulated.

A side-aspect that greatly enriches the book and makes it a “pageturner” is the repeatedly indented depiction of childhood in Vienna, the emigration of the Jewish family to the USA during the time of Austria's connection to the German Reich, the special position of Jewish culture for Eric Kandel about his entire life and work and the bow into the 2000s, in which Eric Kandel tries to advance the historical reconstruction of Austrian responsibility for the rise and work of the National Socialists through his meanwhile outstanding position. The literature quoted by him, which take up this topic or present it with a contemporary novel narrative, but also the quotes of philosophical and psychiatric basic literature, are also well worth reading.
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Emil B
5.0 out of 5 stars A great book about biology of mind
Reviewed in the United States on 15 November 2006
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This is an extraordinary book about neuroscience , physiology, molecular biology and neurobiology and also about people and history. I bought the book with the intention to satisfy my curiosity in the latest developments in the science of mind. I was ready to handle an experience of reading through dry, complex theories and do some hard work of extracting information that I can make sense with my limited knowledge. Surprisingly, the book has none of that; it is written so well, as if it is the transcript of an one on one conversation between friends, so captivating, so clear and so human. I could not let go of it, reading until small hours when reluctantly, I had to go to sleep so next day I could show up at work in a reasonable shape.

The book interweaves threads of science, personal life stories, career, friends, Jewish history, Nobel prize ceremony and biotechnology. The main story is about neuroscience, with emphasis on personal scientific work that culminated with Nobel prize award in 2000. The book can be divided in following sections: personal life, history of neuroscience and molecular biology, short term memory, long term memory, complex behavior and DNA, consciousness, mental illnesses, the experience of receiving Nobel prize, Austria and its relationship with Jewish community in the past and today and an insight analysis of trends in biotechnology from a business point of view.

The book is focused on the biology of short term and long term memory. Eric does an excellent job explaining the evolution of neuroscience up to the point when he started his career, so the reader has a good understanding of contemporary issues and of the formation of neurobiology. I liked a lot the fact that Eric Kandel kept the level of detail in balance and put the explanations in the perspective of human evolution. I loved how he classifies the mechanisms of learning as being either Kantian or Lockean: we are a combination of genetics and learned life experience. It is this philosophical approach that is constantly felt through the whole book that gave me a sense of direction and purpose of his work. His logic is very neutral (objective), in the sense that he refers to our mind as the result of an evolution based on laws of physics, chemistry and genetics. This is a stark contrast with the approach of psychoanalysts during most part of the 20th century that puts so much emphasis on personal interpretation based on patient confessions that transcends biological reality . This is another aspect of the book that astounded me: despite the fact that he is so methodical about deciphering the way the mind works using a reductionist approach, thus implying that mind is a complex and large collection of simple neuronal structures, he is so human when he talks about his family and friends. He talks a great deal in an emotional way (happy, sad or humorous) about his friends, mentors, colleagues and students. His emotions, infinitely more complex than any of Aplysia's rituals, in a way, are a reminder of the huge work that still needs to be done until we will understand how our neurons can create such sophisticated behavior.

The book talks in great detail about the structure and functions of neurons, with lots of details about how electrical and chemical signals work at the synaptic level. Eric Kandel did a great job describing the molecular and ionic hypothesis, signaling, protein manufacturing, genetics and their role in memory. However, I thought that it helped me a lot my prior understanding of how genes expression works, because the book does not provide much assistance in that area. This is especially important for readers who are more interested in aspects of long term memory and complex human behavior.

I found fascinating the section dedicated to consciousness. As usual, Eric takes the reader through the history of genetics and then spending more pages on the work of Francis Crick and Christof Koch and current developments.

Eric closes his book with a personal analysis of the current state of the science of mind, what is next and his sharing with the readers of how one should plan a career in general, based on his personal experience. Excellent book!
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Jean-Paul Azam
5.0 out of 5 stars You'll Never Forget it
Reviewed in France on 23 March 2016
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Erik Kandel won the Nobel Prize for his path-breaking work on the cerebral mechanisms that produce memory. In this popular science book, he offers an illuminating description of his own research spanning several decades in relation to the general advancement of the topic. He knows how to use simple pictures to convey the key points and the reader learns painlessly quite a lot about his own brain and how his own mind functions. Moreover, Kandel blends his own memories with his narrative, from his beloved Vienna that his family had to leave when the Nazis took over, to New York, where he spent the rest of his life.
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Silvia
5.0 out of 5 stars imposing
Reviewed in Italy on 22 August 2013
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One of the best books I've ever read, just great. The life story of a scientist is told by introducing the most important neuroscience concepts of recent decades, also excellent for reviewing many concepts of biology, explained with extreme clarity and precision.
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Gabriel Paiva da Silva Lima
5.0 out of 5 stars Magnanimous
Reviewed in Brazil on 11 June 2014
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For those who are interested in and like neuroscience.
The book contains part of the life biography of one of the greatest neuroscientists of our time and his fascination with what makes us human: the mind and, more specifically, memory. In it, Kandel first describes the intellectual environment of Vienna at the beginning of the 20th century and the conflicts that marked his life trajectory. Throughout the plot, he describes his experiments in favor of a science of the mind until, finally, he arrives at experiments on memory fixation and its relationship with notions of space. Finally, a must read for those who are interested or work in areas such as neurology, neuroscience, neuropsychology, psychoanalysis, psychiatry.
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Ron Wates
5.0 out of 5 stars An engaging mix of factual knowledge and reminiscence
Reviewed in the United Kingdom on 10 February 2011
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This is one of the most interesting books that I've read in recent times. In a sense, it does what it says on the tin. It describes, with authority, the early stages in the development of neuroscience. However, it does much more than that.

I think its attractiveness lies in the way it successfully merges approaches which are, by their nature, difficult to combine. For instance, the author combines a description of Freudian psychoanalysis with a 'hard-headed' view of deterministic science; he combines reminiscences of his childhood in Nazi Austria with his Nobel-winning knowledge of neuroscience.

I thoroughly recommend this book to anyone who wishes to gain a sound understanding of the ideas and developments of neuroscience. This is delivered with a feeling of the excitement of being closely involved with the advances in the science and also a knowledge of the people who were involved.
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Amazon カスタマー
5.0 out of 5 stars I would like you to read by the first grader of the Faculty of Medicine.
Reviewed in Japan on 13 April 2019
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The paper quality was poor, but the content was very interesting.I would like students who start biology to read it.
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Julie De Merchant
5.0 out of 5 stars Excellent scientific read
Reviewed in Canada on 11 March 2019
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Very informative and detailed account of a life's work in memory research. A interesting scientific book, well written.
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Amazon Customer
5.0 out of 5 stars easy to read
Reviewed in Japan on 20 April 2013
Format: KindleVerified Purchase
The book is the autobiography and workbook of Dr. Eric Kandel who is the author of Principles of Neural Science.
Although it is a kindle version, it is originally written in very plain English, so you can read Thurasla.It is easy to read like an example.I think it is also the best way to review the historical aspects of neuroscience.
This price was bargain with this fulfillment level.You can feel the depth of the US e-book industry.
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biagio palese
5.0 out of 5 stars Everything is perfect
Reviewed in Italy on 11 November 2013
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no damage everything arrived on time, great packaging and text in perfect condition.. no negative point really great purchase I recommend it to everyone
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A. Menon
5.0 out of 5 stars Immensely readable discussion of memory following the authors personal history
Reviewed in the United States on 7 May 2012
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I bought this book when it was first published but for some reason got distracted while reading it the first time and put it down. Luckily i recently decided to pick it up again- the book is fantastic. In search of Memory is a mixture of autobiography and science. The author constructs the book around his own history and his own motivation both for study of memory. The book is split into 6 sections with the first and last focused on personal history and the middle four focused on the author's work. All is engaging and readible and highly recommended, I will give a brief overview of the sections.

In the first section the author describes his childhood in Vienna with the Nazi invasion and the persecution he and his family faced- he describes the hardships faced and the journey taken to go to the US. In this section the stage is set to pose the questions about how memory works. In particular, how memories can be so clear so far from the date of experience in certain situations and where this permanence is formed and stored is pondered. Though few can empathize with the author's experience all can sympathize with the questions about the basis for memory.

The author works chronologically and goes through his early history working with biological and neurological questions. Practical neuroscience and biological problems are considered and so is the authors journey that took him to study the right system to consider memory. The author throughout the book makes it a point to argue that finding the right simple system to analyze that can give broader implication is at the heart of putting oneself in a position to make progress. The author settled on the sea slug Aplysia. So too are discussed were the experience of the author in first monitoring of action potentials in the squid nervous system. A creature with nerve cells relatively easy to monitor.

The author moves onto trying to monitor change in the nervous system after becoming comfortable with the Aplysia's biology. Reflex behaviour is studied and the monitoring of nerve cells is examined when presented with various stimulus. The chemical reactions that take place within the cell and the neurotransmitters that are associated are discussed and in particular the mechanics of short term memory adaptation and implication to behaviour are discussed in detail through the results of experiments done. The author continues on to pose questions about long term memory and how short term and long term though different, must be associated somehow. The mechanics for this are not understood but insight is provided by the author and the subject matter is fascinating.

The author continues in complexity and starts to discuss things like perception and spacial awareness. Spacial awareness is definitely an arena to explore how memory works given our spacial awareness and that of most creatures is a function of nature in initial architecture as well as environment which determines how the memory implicit in a mental map is formed. This process is being explored in current science and the idea of paying attention is also discussed.

The author moves on to modern biomedical progress and how understanding memory processes in mice has provided a means to develop insight and treatment into memory related diseases. The author discusses how biology is an incredibly important part for the future of psychiatry. In particular the rigour of science should be applied to psychiatry to get an objective measure of results. Interaction of people is shown to be very important for developement and treatment is not chemistry when it comes to social disorders and mental disorders like depression and schizophrenia. The author also walks through some of his thoughts on the collaboration of the private and public sector in the field of pharmaceuticals.

The author concludes with his receiving of the Nobel prize. It is a return to the autobiographical aspect of the book and the author describes how he revisited Vienna and some of the discourse engaged in while there. It is a reasonable end to an otherwise fascinating and informative book.
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sohamdoshi
5.0 out of 5 stars 10 star.Must Read.Bible.
Reviewed in India on 1 June 2019
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Simple language.well classified in chapters and headlines within chapters.photos r there.writen by noble prize winner neuro scientist,so u can get the feel of clarity of mind and neurology explained from basics to present day.it is not just about memory,whole functioning of nervous system is explained.there r many noble winner scientists but kandel is special becasuse he has written this book which can be read by common man.
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Zivot Phoenix
5.0 out of 5 stars Enchanted!
Reviewed in Canada on 9 November 2013
Format: KindleVerified Purchase
I am still reading the book, but I am already sue it is worth my time and the money I paid for it. The author generously share a piece of his autobiography to contextualize the science. I am talking about the book and will buy a hard copy to give as a gift.
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Carl Abensperg-Traun
5.0 out of 5 stars Scientific findings on the brain and its secrets
Reviewed in Germany on 12 November 2024
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Kandel never disappoints
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EV
5.0 out of 5 stars A pleasure and an education.
Reviewed in the United Kingdom on 2 July 2007
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I thoroughly enjoyed reading this book. The combination of autobiography and science makes it unique. The author acts as an enthusiastic guide to a fascinating area of scientific research. Perhaps there are too many reminiscences about Kandel's colleagues but this adds to the humanity of the story. In no way does it resemble a textbook but this book taught me more about the biology of the brain than any other. I wish I had read it when I was considering university options.
10 people found this helpful

Joel Medici
5.0 out of 5 stars Top-notch research
Reviewed in Brazil on 14 December 2020
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EXCEPTIONAL
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キミチョゲ
5.0 out of 5 stars A sample of concise and logical sentences.
Reviewed in Japan on 16 January 2014
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The autobiography of the Nobel Prize in Medicine and Science scientist who revealed the mechanisms of memory, especially the mechanisms of short-term and long-term memory using amphrasic.It's a great book, like a simple and logical example.
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Renjith Viswanathan
4.0 out of 5 stars Good
Reviewed in India on 9 June 2020
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Well written
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Richard B. Schwartz
5.0 out of 5 stars A Wonderful Book
Reviewed in the United States on 15 February 2014
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This is a wonderful book, but it is actually two books in one. It is the autobiography of a Nobel laureate and, along the way, a history of modern studies of the brain and memory. Kandel and his family escape Nazi Vienna and come to New York. He studies medicine, intending to be a psychoanalyst, but then discovers the new science of the mind—molecular biology, neuroscience and cognitive psychology. He makes brilliant strides through the in-depth study of a particular creature, Aplysia, a large sea snail. As his new life unfolds in the United States (principally at Columbia), so does the study of the brain and the two become inextricably linked.

Initially studying the humanities, Kandel is, like most wise people, broadly educated. One of the ongoing themes of In Search of Memory is the manner in which dry neuroscience anticipates and reinforces wet neuroscience. Humor theory in antiquity and the renaissance . . . the empiricism of the British philosophers . . . the Kantian ‘categories’ . . . the hypothetical, abstract constructs of Freud . . . all find some degree of confirmation in the discoveries and tentative conclusions of laboratory scientists in the 20th and 21st centuries.

The writing is very lucid and even when the story becomes increasingly complex, with the discovery of additional neurotransmitters and electro/chemical processes, non-scientific readers are able to follow the exposition and line of argument.

The book also looks to the future, with the daunting challenges of understanding consciousness and the teasing possibilities of integrating neuroscience with such fields as sociology.

Kandel is likable, engaging, and courageous, as when he presses contemporary Austrians to come to terms with their complicity in National Socialism and the holocaust. He is a cultured man, complementing his knowledge of science with his love of the arts and music. He is also a generous man, sharing the limelight with collaborators and colleagues. In some passages his autobiography constitutes an examination of the sociology, economy and ethos of those who do serious science.

If you are interested in following the life of a very interesting man as well as following the course of modern neuroscience, this would be an ideal place to start. It is also rich in its illustrations and it includes a 20+ page glossary which is very, very helpful.

Highly recommended.
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Amazon Customer
5.0 out of 5 stars Both an informative history of the 20th century and all ...
Reviewed in the United Kingdom on 3 November 2017
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Both an informative history of the 20th century and all the history behind the science of memory. Really well written .
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Carolina Thomas
5.0 out of 5 stars Super motivating story for young neuroscientists
Reviewed in Germany on 4 August 2016
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The book is also the biography of E. Kandel and a history of neuroscience. It is fascinating and definitely motivating for neuroscientists, but also for those who are curious about the secrets of the brain.
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Dr. Bruno Widmann
4.0 out of 5 stars In Search of Memory, Eric R. Kandel
Reviewed in Germany on 1 June 2014
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It can certainly be qualified as a building stone within the scope of neurosciences, psychology and possibly psychotherapy.
New basic reliable aspects of logic considerations.
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Sue Ibrahim
4.0 out of 5 stars This is a book which blends autobiography and science beautifully. The autobiographical parts are fascinating in themselves
Reviewed in the United Kingdom on 16 October 2014
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This is a book which blends autobiography and science beautifully. The autobiographical parts are fascinating in themselves, but the development of the new science of mind is obviously the key aspect of the book and this is made as accessible as possible (though still quite complex for the lay reader). I found the later chapters a little disappointing as the momentum of the developments seems to tail off and it becomes more hypothetical about what could be achieved, but overall it is well worth reading if you want to understand more about the workings of the mind without doing a high-level academic study of the subject.
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Amazon Customer
3.0 out of 5 stars Flimsy binding and poor quality paper
Reviewed in India on 11 September 2017
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The rating is not for the content but the physical form of the book. Flimsy binding and poor quality paper. The content will always receive 5 starts from me. Most recommended read for anyone who is trying to get a sense of history of scientific research in the field of memory.
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A M
4.0 out of 5 stars A combination of autobiography and neural biology
Reviewed in the United States on 1 April 2025
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The book is a mix of an autobiography, a clear and enjoyable survey of molecular neural biology, and ideas about science, the mind, and consciousness.
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Gabriele Bohn
5.0 out of 5 stars A book worth reading in the age of scientific change
Reviewed in Germany on 23 April 2013
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It was very exciting to read and brought the not always simple matter to the reader very understandable and entertaining. For those who are interested in the functioning of the brain and the collaboration of scientists in American institutions.
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J. Owen
5.0 out of 5 stars Read, Learn, and Remember
Reviewed in the United States on 4 August 2009
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In Search of Memory is one of the best books I have read this year. It combines autobiography, with an elegant and simple explanation of scientific and neurologic materials. It also reads like a "Who's Who" of neuroscience.

Eric Kandel can write, tell a tale, and give insight into a variety of topics. He detailed his personal story from being a child in Austria, leaving after Kristallnacht 1938, and finding his path in life. He explains Kristallnacht and the implications of its impact on mankind.

I appreciated his inclusion of his memories as an Austrian Jewish child fleeing the country, and his return visits during his adult life where he brought his insight forward into the political realm. He wove his personal and professional stories intricately detailing his very exceptional life.

For example, Dr. Kandel writes a detailed account of the events leading up to, during and after his trip to Sweden to accept the Nobel Prize, with two other colleagues, during 2000. Therein lies a great human interest story, as well as, description of international celebrity.

The author shares with his reader, that he has an interest in why people do what they do, how they remember and what makes science. He writes extremely well, chronicling his journey with historical, political, psychological, and scientific backdrops. I was very impressed and impacted by the variety of photos included from his personal collection, as well as, explanatory diagrams and educational materials; an Index, Notes and Sources, and an excellent Glossary.

While reading In Search of Memory, I bookmarked extensively, and kept thinking of all the people that I would give this to, as a gift. This is a superb book. I liked the quote that captured it all, in three sentences:

"Few can interlace their autobiography with the evolution of a scientific paradigm. Even fewer
can weave such a story seamlessly. Eric Kandel is one of these." Yadin Dudai, Nature.
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Anaesthetics trainee
5.0 out of 5 stars Brilliant Read
Reviewed in the United Kingdom on 4 January 2013
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This book is a great read, I have never been particularly interested in autobiographies but Kandel weaves so much science and technical detail into the story it become really enjoyable. It is also nice to learn about some of the history he incorporates into the story from his childhood. A fascinating read.
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Willy Huber
5.0 out of 5 stars How does the brain work? Biological Basics
Reviewed in Germany on 8 April 2019
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Very interesting, needs some scientific knowledge..
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Loretta Brennan
3.0 out of 5 stars A little heavy for the average layman
Reviewed in the United States on 19 January 2019
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But well done. Not a quick read though and a bit over my head.
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alex13
5.0 out of 5 stars fascinating read
Reviewed in the United Kingdom on 14 March 2014
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recommended reading for a MOOC course I was studying, this is both an interesting autobiography and a fascinating insight into some of the workings of the brain
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SVJ
5.0 out of 5 stars In search of memory
Reviewed in Germany on 19 October 2013
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Book maintained in very good condition, like new. Since I am a neurobiologist as well, this book is amazingly inspiring to me. However it is good for general reading as well.
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jan
5.0 out of 5 stars quality delivery and value
Reviewed in the United Kingdom on 23 December 2023
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good
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Mark B Gerstein
5.0 out of 5 stars Thoughts on 3 of Kandel's books on the Brain: Different Views of the Elephant
Reviewed in the United States on 25 June 2022
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Here, I summarize my thoughts on three books by Eric Kandel: The Disordered Mind, In Search of Memory, and Reductionism in Art and Brain Science: Bridging the Two Cultures. Eric Kandel is a great American scientist and winner of the Nobel Prize. Interestingly, he started his career as a humanities major at Harvard, and he writes very much in that tradition.

The books cover various topics, including psychiatric disorders such as schizophrenia, the molecular basis of memory, and the relationship between the subconscious and art, and incorporate his recollections of his life journey and world history, particularly related to Vienna. While the books focus on different things, they all look at different aspects of the same subject, like taking different views of one elephant.

When discussing psychiatric diseases, I like how Dr. Kandel described the root causes and history of schizophrenia and autism. These diseases trace much of their early history to Vienna and some famous early brain scientists there, such as Kraepelin and Asperger. Within the topic of memory, I liked Dr. Kandel's reflection on how memory is stored in synapses from inhibitory and excitatory neurons, and, in parallel fashion, these synaptic memories turn into molecular events and gene expression through activating and repressing transcription factors of the CREB family. Kandel also talks about his own memories. It was striking how Vienna was such a center of scholarship in the early 20th century and so quickly fell into tragedy with the advent of the Nazis and has changed dramatically since then.

Finally, I enjoyed reading about Dr. Kandel's relationship between the subconscious and art. He talked about how many recent artists have tried to move beyond the conscious representation of the figure and harness their subconscious and how abstract art can play into our deep mental processes, such as face recognition.

Overall, I found these books very interesting reads that give an encompassing picture of both the mind and a great person.
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Goff
4.0 out of 5 stars Art & the biology of mind
Reviewed in the United Kingdom on 28 February 2013
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The book comes in three sections.
The first is a romp through the history of art at the start of the 20th century; it has been done better by Gombrich.
The second is a primer on recent developments in the biology of the mind, of which the author is a celebrated pioneer.
The third seeks to show how that new understanding of the mind, based on biology, might - I say might - help to explain why we appreciate art. Worth reading, but not convincing. Perhaps those involved in the biology of the mind need the rest of the 21st century to get their act together.
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